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Advancements in CAR T-Cell Therapy for Acute Myeloid Leukemia: Overcoming Barriers and Optimizing Therapeutic Outcomes
ACTIVITY DESCRIPTION
This activity consists of a recorded presentation from the "Essentials of Oncology and Transplant Management for the Health Care Team" conference held in Scottsdale, Ariz., April 11-12, 2024.
There has been considerable success of chimeric antigen receptor (CAR) T-cell therapy targeting CD19 in B-cell malignancies; however, the challenges posed by acute myeloid leukemia (AML) remain. This session aims to explore CAR T-cell therapy in the context of AML. It will review recent advances in novel epitope engineering strategies to reduce on-target/off-tumor toxicity and challenges in generating effective T-cell therapies. The ongoing efforts in identifying potential CAR-T cell targets for AML and potential future directions for CAR T-cell targets will be discussed.
Provided by
This activity is provided by Optum Health Education.
Commercial support
There was no commercial support received for this activity.
Target Audience
This activity has been designed to meet the educational needs of case managers, coders, dietitians, dietetic technicians, managed care nurses, nurses, nurse practitioners, pharmacists, pharmacy technicians, PAs, physicians, psychologists, social workers, transplant coordinators and other health care professionals.
Learning Objectives
At the end of this educational activity, participants should be able to:
- Identify the main challenges in applying CAR T-cell therapies to AML, including understanding tumor heterogeneity and the significance of off-tumor effects.
- Evaluate the potential of epitope engineering to reduce on-target/off-tumor toxicity and describe the concept of multiplex epitope engineering.
- Analyze the latest developments, including combination drug therapy and targeted CAR T-cell constructs, in enhancing the efficacy and specificity of CAR T-cell therapies for AML.
Presenter
Navneet Majhail, MD, MS, FASTCT
Physician-in-Chief of Blood Cancers
Director, Sarah Cannon Transplant and Cellular Therapy Program at TriStar Centennial
Sarah Cannon Cancer Institute
Planners
Elizabeth Albert, MD
Clinical Activity Manager
Optum Health Education
Matthew Cooper, MD
Mark B. Adams Chair in Transplant Surgery
Chief, Division of Transplant Surgery
Director, Solid Organ Transplant Service Line
Froedtert Memorial Lutheran Hospital;
Director, Solid Organ Transplantation
Children’s Wisconsin;
Tenured Professor of Surgery
Medical College of Wisconsin
Rebecca Gleason, RN, CCM
Activity Manager
Optum Health Education
Katie L. Lo Coco RN, BSN, CCTC, CCM
Clinical Operations Manager for Transplant Solutions M&R
Optum Health
C. Fred LeMaistre, MD
Senior Vice President
Senior Vice President, Market Operations
Physician-in-Chief, Hematology
Sarah Cannon
Navneet Majhail, MD, MS, FASTCT
Physician-in-Chief of Blood Cancers
Director, Sarah Cannon Transplant and Cellular Therapy Program at TriStar Centennial
Sarah Cannon Cancer Institute
Tina Rydland, PharmD
Executive Pharmacy Consultant
Disclosures of relevant financial relationships
In accordance with the Accreditation Council for Continuing Medical Education's (ACCME) Standards for Integrity and Independence in Accredited Continuing Education, OptumHealth Education (OHE) requires all those in control of educational content to disclose their financial relationships with ineligible companies within the prior 24 months. Ineligible companies are defined by the ACCME as companies whose primary business is producing, marketing, selling, re-selling, or distributing health care products used by or on patients. Individuals must disclose all financial relationships, regardless of the amount, with ineligible companies and regardless of their view of the relevance of the relationship to the education. OHE ensures that the content is independent of commercial bias.
Financial Relationship Key
A-Advisory Board
CT-Clinical Trial
C-Consultant
E-Employee
G- Grant/Research Support or Funding
I-Stocks and Other Ownership Interests
S-Speakers’ Bureau
O-Other Financial or Material Support
Navneet Majhail: Anthem Inc (C); HCA Healthcare (I)
All relevant financial relationships have been mitigated.
The remaining faculty and planners have no financial relationships to disclose.
Method for calculating CE credit
CE credit was calculated by the complexity of content.
Accreditation statement
In support of improving patient care, this activity has been planned and implemented by Optum Health Education. Optum Health Education is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE) and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.
Credit designation statements
This activity was planned by and for the health care team, and learners will receive 1.00 Interprofessional Continuing Education (IPCE) credits for learning and change.
Physicians
Optum Health Education designates this enduring activity for a maximum of 1.00 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
PAs
The American Academy of PAs (AAPA) accepts credit from organizations accredited by the ACCME.
Pharmacists/Pharmacy technicians
This activity is approved for 1.00 contact hours (0.10 CEUs) in states that recognize ACPE.
Attending the full program will earn 1.00 contact hours (0.10 CEUs).
Unique activity number: JA0007123-0000-24-038-H01-P/T
Nurses
The participant will be awarded up to 1.00 contact hours of credit for attendance and completion of supplemental materials.
Nurse practitioners
The American Academy of Nurse Practitioners Certification Program (AANPCP) accepts credit from organizations accredited by the ACCME and ANCC.
Dietitians
Completion of this RD/DTR profession-specific or IPCE activity awards CPEUs (One IPCE credit=One CPEU).
If the ac
tivity is dietetics-related but not targeted to RDs or DTRs, CPEUs may be claimed which are commensurate with participation in contact hours (One 60 minute hour=1 CPEU).
RD's and DTRs are to select activity type 102 in their Activity Log. Performance indicator selection is at the learner's discretion.
Psychologists
Optum Health Education is approved by the American Psychological Association (APA) to offer continuing education for psychologists. Optum Health Education maintains responsibility for this program. 1.00 CE hours.
Social workers
As a Jointly Accredited Organization, Optum Health Education is approved to offer social work continuing education by the Association of Social Work Boards (ASWB) Approved Continuing Education (ACE) program. Organizations, not individual courses, are approved under this program. State and provincial regulatory boards have the final authority to determine whether an individual course may be accepted for continuing education credit. Optum Health Education maintains responsibility for this course. Social workers completing this course receive up to 1.00 enduring continuing education credits.
Attendance
A certificate of attendance will be provided to learners upon completion of activity requirements, enabling participants to register with licensing boards or associations that have not been preapproved for credits. To apply for credit types not listed above, participants should use the procedure established by the specific organization with which they wish to obtain credit.
Available Credit
- 1.00 ACPE - Pharmacists
- 1.00 ACPE - Pharmacy Technicians
- 1.00 AMA - Physicians
- 1.00 ANCC - Nurses
- 1.00 APA - Psychologists
- 1.00 Attendance - General Attendance
- 1.00 CDR - Dietitians
You must be logged into your account to participate in this activity. Get started by clicking “Register” and following the instructions. At the end of the activity, you will be able to view, save or print your certificate of participation. A complete listing of all of your activities can be found under “My Account,” “My Activities.”